Herbal Contraindications & Drug Interactions

Fourth Edition

by Francis J. Brinker, N.D


This text scrupulously distinguishes between what is known through empirical clinical observations such as case reports and the data obtained from modern clinical human studies, as well as different types of laboratory research on animals and with tissues and cells, citing over 2700 medical and scientific sources to document these findings. In addition, the type of preparation studied is described to emphasize differences between preparations from the same herb. Conflicting results are utilized to put these issues in context. This fourth edition further highlights those combinations of herbal preparations with drugs shown to beneficially enhance therapeutic activity or reduce adverse effects, identified for 98 of the 321 herbs listed in the main text.
In addition, extensive appendices organize information on these 321 herbs and additional herbal remedies into categories addressing specific cautions, interactions with particular types of drugs, precautions for mothers, infants and children, drug interactions with vitamins and minerals, and advantageous combinations with medicines used for inflammations, infections, cancer, and for addressing substance abuse. The appendix sections addressing herbal influences on drug absorption and metabolism involving transport proteins, cytochrome P450 isoenzymes, and conjugating enzymes are the most extensive compilations available anywhere.

Free updates and additions to Herbal Contraindications and Drug Interaction 4th edition are available until the publication of the 5th edition, click here
Also available in Kindle format from Amazon.
To access or download the HCDI 4th edition citations 1 - 2708, click here.
A summary of Contraindications, Interactions and Adjuncts categories and abbreviations are available on this free bookmark

Paperback, 603 pages;
$68.70 ISBN 978-1-888483-14-7
Item #

Francis Brinker is one of the most reliable, thoughtful and authoritative botanical writers of our time. In this new edition of his now classic text, ... Francis’ research takes the issue of herb-drug interactions into a new realm—one that transforms this from a worrisome possible problem to a potential solution for the many patients and physicians who seek an integrated medical model that incorporates both herbal products and Western drugs safely.
— Aviva Romm, M.D., midwife, herbalist President, American Herbalists Guild Medical Director, American Herbal Pharmacopoeia
One of the best features of this edition, and it is characteristic all of his writings, is the extreme care that Dr. Brinker has taken to carefully explain each section of the book, to assess each of his over 2000 references in detail, and to caution clinicians and researchers alike that in a clinical context all herbs are not equal unless we know how and what was extracted, the dosage form used, and the amount administered.
— Paul Richard Saunders, Ph.D., N.D., DHANP Professor of Materia Medica, Canadian College of Naturopathic Medicine
Kudos to Francis for once again, plowing through the voluminous mountain of theoretical data that exists, and organizing it in a sane, honest, thoughtful, useable guide that keeps us up to date and frees our time to be with patients.
— Jillian Stansbury, N.D. Chair Botanical Medicine Dept., National College of Natural Medicine
This is a book I would never want to do without in my clinical practice, my research into botanicals, or my counseling of patients about the safe use of plant medicines ... Absolutely setting this book apart ... is the section on Complementary Adjuncts.
— David Kiefer, M.D. Clinical Instructor of Family Medicine, University of Washington Adjunct Faculty, Bastyr University School of Naturopathic Medicine
Practicing the art of 21st century medicine mandates an understanding of the benefits and pitfalls of herbal remedies. ... All practitioners crave a single comprehensive, authoritative, and accessible botanical medicine resource to run to when need presents. Without question, this is the one.
— Russell H. Greenfield, M.D. Assistant Clinical Professor of Medicine, UNC-Chapel Hill School of Medicine Editor, Alternative Medicine Alert